I thought Itoje was a little unlucky.
One offside was given when the ball was already out, and he was also penalised for a deliberate knock on when he knocked it down from the scrum half's hands.
But by then the ref was already looking out for him, so he should have known and been less "in the ref's face" by then.
The scoreline flattered Wales, because England went chasing the game at the end and forced situations they shouldn't have, and wouldn't if they were in the match.
Which is why the 2 tries that weren't (and niether were tries) made all the difference.
England are still unable to think their way through a tough match. They are one-trick ponies, despite all the "experience" in the team, and while there are still like that, they do not really deserve to win much. Which is a shame.