I'm aware of the difficulties some people have with SSRIs however mine have been life-changing. Initial side-effects included headaches and nausea but perseverance was the key, along with reducing my dosage and then incrementally increasing it until I felt I was getting sufficient benefit.
Quite honestly, I can't imagine not using them now. I know I'll have to come off at some point though.
My advice would be for your brother to give them a go but don't expect instant results, it takes around twelve weeks to feel the benefit.
Best of luck and please PM if you'd like to discuss.