We spent 3 nights there during a tour which also took in Nashville and Memphis. Stayed in a great hotel called Peter & Paul if I remember correctly … walking distance into the night life centre but far enough away not to be disturbed.
you of course need to witness Bourbon Street , if not actually participate depending on your personal prefs.
We enjoyed a very touristy swamp tour with the obligatory Crocs and wild boars. A walk round the one of the graveyards was memorable, and we also drove out to the Whitney Plantation, which diverges from the other romantic tours in that it focuses on the life of the slaves that fueled them - it was a fascinating and humbling tour and our guide was incredibly knowledgeable.
https://www.whitneyplantation.org/
http://hotelpeterandpaul.com/