I've done is a couple of times and never had any real issues.
It does take a while to get used to driving on the right and you can randomly forget but get quickly reminded by either the family or the oncoming car I always take it easy for the first few days, local people in a hurry might beep but they'll find their way around you.
As with any hire car, make sure you inspect it thoroughly and get any/all marks/damage put on the paperwork and make sure you take out a damage waiver policy over here, much cheaper than taking out the policy there with the hire company.