Smith and Warner were given a hostile reception at the Hampshire Bowl, with both booed at the start of their innings and after being dismissed, while former captain Smith was also booed after making 50 and again when reaching a fine century.
Sections of the crowd chanted "cheat" at both players and fans wore costumes referencing sandpaper.
Smith and Warner, along with Cameron Bancroft, were found to have played a role in using sandpaper to tamper with the ball against South Africa in March 2018.
"After the experience of Hampshire, we have a pretty good idea what to expect - we've talked about it a lot and we can put strategies in place," said Langer.
"That said, when it happens it doesn't make it any easier. They are human beings, that's the truth - and that's what I find the hardest.
"I'm a dad and a lot of the time the kids see it. You feel for them personally and they are going to have to have thick skins.
"But I'd be disappointed by any player being booed at any cricket ground, regardless of what country they play for. It's never a good look when that happens."