They will not be awkward to handle but they will be disappointing her and probably berate you for spending the money.
The asymmetrical blade allows you precise cutting while pushing the cut piece away. Used with the other hand, the ‘pushing’ action is against the piece you’re holding, resulting in a less precise cut.
No discomfort as the handle is usually round so makes no difference in either hand.
Oh, and they don’t ‘do’ dishwasher well